Semisynthetic peptide-lipase conjugates for improved biotransformations.
Chem Commun (Camb). 2012 Aug 2;
Authors: Romero O, Filice M, Rivas BD, Carrasco-Lopez C, Klett J, Morreale A, Hermoso JA, Guisan JM, Abian O, Palomo JM
An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.
PMID: 22858661 [PubMed - as supplied by publisher]