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Phosphorylation Regulation

Phosphorylation Regulation of Protein Synthesis

Phosphorylation regulates the activity of eIF4E-eIF4G complex, eIF4E-binding proteins and eIF4E affinity for eIF4G andthe cap structure. Drugs and infections can also effect this regulatory circuit and thereby affect subsequent translation of mRNA, leading to changes in protein levels (Sachs et al., 1997).

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